3. On macromolecular sequences:

There are no or rather scanty reports in the literature on how to make under prebiotic conditions long - say 30 residues - specific sequences of co-oligopolypeptides (or polynucleotides) in many identical copies containing say 5-6 different amino acid residues or 3-4 bases (the Merrifield method cannot be considered a prebiotic method). Methods for homo-polypeptides (chains containing only one type of residue) have been described, but they are in principle not valid for mixtures of different aminoacids - as all rules of copolymeration teach us. Random polymerisation of mixtures of amino acids (which we also we do not know how to make under prebiotic conditions) would produce a wild mixture of different chains, with a circa zero probability to make two identical chains. Do you agree then that we do not know - neither conceptually nor experimentally - how to make macromolecular sequences in many identical copies under prebiotic conditions? And if it so, would you not conclude that the bottom-up approach to the origin of “our” life is made impossible by the very definition of contingency?